Biochemistry
DPP-4
Dipeptidyl peptidase-4 — a protease that rapidly degrades native GLP-1 and GIP.
Definition
DPP-4 cleaves peptides at the N-terminal second position after proline or alanine. Native GLP-1 has a half-life of ~2 minutes due to DPP-4. GLP-1 analogs (semaglutide, liraglutide) are engineered to resist DPP-4 cleavage.
Related terms
Back to the full peptide glossary.