Strong EvidenceResearch Only

Thymosin Alpha-1: What the Research Shows

Also known as: Tα1, Thymalfasin, Zadaxin

A naturally occurring thymic peptide approved internationally for immune modulation, with extensive clinical data in hepatitis and cancer immunotherapy.

This content is for educational purposes only and is not medical advice. Consult a qualified healthcare provider before making any health decisions. Full disclaimer

Quick Facts

Category🛡️ Immune Support
Amino Acids28
Molecular Weight3108.27 Da
FormulaC129H215N33O55
FDA StatusResearch Only
Evidence RatingStrong
Human TrialsYes (30)
WADA StatusNot prohibited
Routessubcutaneous
Last Reviewed2026-03-11

Regulatory Status

Not FDA-approved in the US. Approved in over 35 countries (as Zadaxin) for hepatitis B and as an immune adjuvant. Orphan drug designation in the US for hepatitis B.

Researched Applications

Immune modulationHepatitis B treatmentCancer immunotherapy adjuvantVaccine enhancement

Key Research (1 studies cited)

Thymalfasin: clinical pharmacology and antiviral applications

review

Tuthill CW, et al. (2010) — BioDrugs

Comprehensive review of thymosin alpha-1 clinical data spanning over 100 clinical trials in hepatitis, cancer, and immune deficiency.

Key finding: Thymosin alpha-1 showed consistent immune-enhancing effects across multiple clinical settings, particularly in hepatitis B.

PubMed: 20923259

About this article: Written by the PeptideMark Research Team. Last reviewed 2026-03-11. All factual claims are cited to peer-reviewed sources. PubMed links open in a new tab for independent verification. Editorial methodology · Medical disclaimer

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Last reviewed: 2026-03-11