MOTS-c: What the Research Shows
Also known as: Mitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.
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Quick Facts
Regulatory Status
Not FDA-approved. Research compound. A mitochondria-derived peptide discovered in 2015.
Researched Applications
Key Research (1 studies cited)
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
animalReynolds JC, et al. (2021) — Nature Communications
Study showing MOTS-c levels increase with exercise and administration improves physical capacity in aged mice.
Key finding: MOTS-c treatment improved physical performance and muscle homeostasis in aged mice, mimicking some effects of exercise.
PubMed: 33420028About this article: Written by the PeptideMark Research Team. Last reviewed 2026-03-11. All factual claims are cited to peer-reviewed sources. PubMed links open in a new tab for independent verification. Editorial methodology · Medical disclaimer
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