Growth Hormone Peptides: Secretagogues & Releasing Hormones
Growth hormone secretagogues are peptides and peptide-adjacent compounds that stimulate the body's natural production of growth hormone. This category includes GHRH analogs (CJC-1295, Sermorelin, Tesamorelin), GHRPs (Ipamorelin), and non-peptide secretagogues (MK-677/Ibutamoren). Evidence quality varies significantly — Tesamorelin and Sermorelin have FDA-approval history, while others remain research-only.
5 compounds in this category
CJC-1295CJC-1295 DAC, CJC-1295 without DAC
A growth hormone-releasing hormone (GHRH) analog studied for its ability to increase growth hormone and IGF-1 levels.
IpamorelinNNC 26-0161
A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin.
SermorelinGeref, GHRH(1-29)NH2
A growth hormone-releasing hormone analog with a long history of clinical use for GH deficiency diagnosis and therapy.
TesamorelinEgrifta, TH9507
An FDA-approved GHRH analog used for HIV-associated lipodystrophy, with research into broader metabolic and cognitive applications.
MK-677Ibutamoren, Nutrobal
An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.