Safety Profile
Ipamorelin Side Effects: Frequency & Severity
Ipamorelin is the most selective ghrelin receptor agonist, producing minimal cortisol or prolactin elevation. Side effects are uncommon and mild.
Educational content only. This page is compiled from published research for reference and is not medical advice, diagnosis, or treatment. Readers should verify claims against primary sources and consult a qualified healthcare provider before making any health decisions. Full disclaimer.
Common side effects
1Injection site reactions
Mild and transient.
Uncommon side effects
4Headache
Typically mild.
Flushing
Less than other GHRPs.
Mild water retention
Due to GH effects.
Increased hunger
Ghrelin receptor activation increases appetite.
Rare side effects
1Fatigue
Rarely reported.
Contraindications
- Active malignancy
- Pregnancy
- Known hypersensitivity
Drug interactions
- Limited clinical interaction data
- Additive GH release when combined with GHRH analogs
Special populations
Not FDA approved. Not recommended in pregnancy or active malignancy.
Overall safety summary
Ipamorelin has one of the cleanest side effect profiles among GH-releasing peptides due to its selectivity. Unlike GHRP-2 and GHRP-6, it does not significantly elevate cortisol or prolactin.
Ipamorelin side effects: FAQ
Does ipamorelin increase cortisol?
Unlike GHRP-2 and GHRP-6, ipamorelin has minimal impact on cortisol or prolactin release — one of its main pharmacological advantages.