In VitroPubMed ID: 10812144·2000

GH-Releasing Hormone Receptor Expression in Pancreatic Islet Cells and Effects of Sermorelin on Insulin Secretion

Ottaway CA, Biddle JW, Greeley GH Jr, et al.

Life Sciences, 2000

Key finding

Sermorelin stimulated insulin secretion from isolated pancreatic islets by 340% independent of GH, indicating direct pancreatic action.

Summary

Mechanistic study demonstrating GHRH receptor expression on pancreatic beta cells and direct sermorelin stimulation of insulin secretion.

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Related compound

SermorelinL4

A growth hormone-releasing hormone analog with a long history of clinical use for GH deficiency diagnosis and therapy.

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