In VitroPubMed ID: 1565522·1992

Sermorelin Stimulates Growth Hormone Secretion via GHRH Receptor in Somatotroph Cells

Müller OA, BOutputstädter M, Hallensleben K.

Neuroendocrinology, 1992

Key finding

Sermorelin activated cAMP signaling in somatotrophs with EC50 of 18 nM; GH secretion increased 580% at 1000 nM.

Summary

Cellular study demonstrating sermorelin binding and G-protein coupling to GHRH receptors on cultured pituitary somatotroph cells.

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Related compound

SermorelinL4

A growth hormone-releasing hormone analog with a long history of clinical use for GH deficiency diagnosis and therapy.

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