Human RCTPubMed ID: 16816556·2006

REDUCE-1: Tesamorelin in HIV-Associated Lipodystrophy — A Randomized Controlled Trial

Grunfeld C, Thompson M, Brown SJ, et al.

AIDS, 2006 · n = 412

Key finding

Tesamorelin reduced visceral AT by 18.3% versus 8.3% placebo (p<0.001); improvement sustained at 26 weeks post-treatment.

Summary

Phase 3 RCT of tesamorelin 2mg daily versus placebo in HIV-positive patients with lipodystrophy measuring visceral adipose tissue by CT.

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Related compound

TesamorelinL5

An FDA-approved GHRH analog used for HIV-associated lipodystrophy, with research into broader metabolic and cognitive applications.

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