In VitroPubMed ID: 17878917·2007

Epithalon Effects on Cellular Senescence and p16/INK4a Expression in Aging Fibroblasts

Krutko VI, Khavinson VKh, Malinin AV.

Bulletin of Experimental Biology and Medicine, 2007

Key finding

Epithalon extended fibroblast lifespan by 28%, reduced p16/INK4a expression by 42%, and maintained telomere length over multiple passages.

Summary

In-vitro study examining epithalon effects on replicative senescence, senescence markers (p16, p21), and cellular lifespan extension.

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Related compound

EpithalonL2

A tetrapeptide studied for its potential to activate telomerase and extend cellular lifespan, primarily in Russian research.

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