Human PilotPubMed ID: 18252790·2008

GHRH Analog Tesamorelin Mechanism of Action: Growth Hormone Secretion and IGF-1 Production in HIV Patients

Johannsson G, Gaillard RC, Rousseau B, et al.

Journal of Clinical Endocrinology & Metabolism, 2008 · n = 45

Key finding

Tesamorelin increased integrated GH secretion 5.2-fold and stimulated hepatic IGF-1 production despite ongoing antiretroviral therapy.

Summary

Mechanistic study of tesamorelin-stimulated GH secretion patterns and IGF-1 production in HIV-positive subjects.

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Related compound

TesamorelinL5

An FDA-approved GHRH analog used for HIV-associated lipodystrophy, with research into broader metabolic and cognitive applications.

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