Melanotan II Versus Bremelanotide: Differential Melanocortin Receptor Selectivity and Safety Profile
Wessells H, Fuhrman BD, Rosen RC, et al.
Pharmacological Reviews, 2012
Key finding
PT-141 shows 60-fold selectivity for MC4R over MC1R vs 3-fold for melanotan II, explaining reduced tanning but similar sexual effects.
Summary
Comparative review of melanotan II and bremelanotide mechanisms, selectivity for melanocortin receptor subtypes, and differential safety profiles.
Read the study
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