Animal StudyPubMed ID: 28093279·2017
Dopamine Pathways Modulation by Melanocortin-4 Receptor in Nucleus Accumbens and Sexual Motivation
Kow LM, Pfaff DW.
Neuroscience, 2017
Key finding
MC4R activation increased dopamine release in nucleus accumbens by 156% during sexual approach; blocked by MC4R antagonist HS014.
Summary
Mechanistic study in rodents demonstrating MC4R coupling to dopamine signaling in nucleus accumbens during sexual approach behavior.
Read the study
The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.
View on PubMedRelated compound
More research on PT-141
Comparison of PT-141 and Flibanserin for Female Sexual Desire Disorder: An Indirect Treatment Comparison
Sexual Medicine Reviews · 2022 · Review
Blood Pressure and Cardiovascular Effects of Bremelanotide in Hypertensive Versus Normotensive Women
Journal of Sexual Medicine · 2021 · Human RCT
Long-Term Safety and Efficacy of Bremelanotide: 1-Year Extension Study in Women with HSDD
The Journal of Sexual Medicine · 2021 · Human Pilot
RECONNECT-1: A Randomized Controlled Trial of Bremelanotide for Female Sexual Desire Disorder
The Journal of Sexual Medicine · 2020 · Human RCT
RECONNECT-2: Phase 3 Trial of Bremelanotide in Premenopausal Women with Generalized Hypoactive Sexual Desire Disorder
The Journal of Sexual Medicine · 2020 · Human RCT