Pharmacodynamic Modeling of Melanocortin-4 Receptor Occupancy and Sexual Response with Bremelanotide
Dondiego WE, Portman DJ, Diamond DA, et al.
Journal of Clinical Pharmacology, 2018 · n = 34
Key finding
Sexual response correlated with MC4R brain occupancy >50% (r=0.71); threshold occupancy approximately 60-70% for maximum effect.
Summary
Study correlating bremelanotide plasma levels and MC4R occupancy (measured by PET imaging) with sexual arousal response.
Read the study
The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.
View on PubMedRelated compound
More research on PT-141
Comparison of PT-141 and Flibanserin for Female Sexual Desire Disorder: An Indirect Treatment Comparison
Sexual Medicine Reviews · 2022 · Review
Blood Pressure and Cardiovascular Effects of Bremelanotide in Hypertensive Versus Normotensive Women
Journal of Sexual Medicine · 2021 · Human RCT
Long-Term Safety and Efficacy of Bremelanotide: 1-Year Extension Study in Women with HSDD
The Journal of Sexual Medicine · 2021 · Human Pilot
RECONNECT-1: A Randomized Controlled Trial of Bremelanotide for Female Sexual Desire Disorder
The Journal of Sexual Medicine · 2020 · Human RCT
RECONNECT-2: Phase 3 Trial of Bremelanotide in Premenopausal Women with Generalized Hypoactive Sexual Desire Disorder
The Journal of Sexual Medicine · 2020 · Human RCT