Human RCTPubMed ID: 31307344·2019

PIONEER 6: Oral Semaglutide Cardiovascular Safety in Type 2 Diabetes

Husain M, Birkenfeld AL, Donsmark M, et al.

New England Journal of Medicine, 2019 · n = 3183

Key finding

Oral semaglutide reduced major adverse cardiovascular events by 26% (HR 0.74, 95% CI 0.52-1.03), HbA1c by 1.3%, with weight reduction of 3.8kg.

Summary

Safety and efficacy trial of oral semaglutide in type 2 diabetes patients with established cardiovascular disease.

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Related compound

SemaglutideL5

An FDA-approved GLP-1 receptor agonist used for type 2 diabetes and chronic weight management.

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