Safety Profile

CJC-1295 Side Effects & Safety

CJC-1295 is generally well-tolerated; most side effects are related to transient GH elevation.

Educational content only. This page is compiled from published research for reference and is not medical advice, diagnosis, or treatment. Readers should verify claims against primary sources and consult a qualified healthcare provider before making any health decisions. Full disclaimer.

Side effects by severity

Common2 effects

Injection site reactions

Redness, itching, mild swelling.

Facial flushing

Particularly in first weeks; typically transient.

Uncommon4 effects

Headache

Usually mild and transient.

Water retention

Mild edema possible due to GH/IGF-1 elevation.

Increased appetite

Related to GH effects.

Numbness/tingling in hands

Carpal-tunnel-like symptoms from fluid retention.

Rare2 effects

Hypoglycemia

Possible with sustained GH elevation.

Insulin resistance

Chronic supraphysiologic GH may impair glucose tolerance.

Contraindications

Active malignancy
Pregnancy and breastfeeding
Known hypersensitivity
Uncontrolled diabetes

Drug interactions

Corticosteroids — may blunt GH-releasing effect
Insulin — may require dose adjustment due to GH counter-regulatory effects

Special populations

Not FDA approved for any indication. Not recommended in pregnancy, pediatrics, or patients with active malignancy.

Safety summary

CJC-1295 is generally well-tolerated in pilot human studies. Side effects are usually related to GH elevation (water retention, carpal tunnel symptoms). Long-term safety data is limited.

Frequently asked

Can CJC-1295 cause gynecomastia?

Gynecomastia is not a commonly reported effect, but theoretical risk exists if GH elevation promotes aromatization in susceptible individuals.