Safety Profile

Ipamorelin Side Effects & Safety

Ipamorelin is the most selective ghrelin receptor agonist, producing minimal cortisol or prolactin elevation. Side effects are uncommon and mild.

Educational content only. This page is compiled from published research for reference and is not medical advice, diagnosis, or treatment. Readers should verify claims against primary sources and consult a qualified healthcare provider before making any health decisions. Full disclaimer.

Side effects by severity

Common1 effect

Injection site reactions

Mild and transient.

Uncommon4 effects

Headache

Typically mild.

Flushing

Less than other GHRPs.

Mild water retention

Due to GH effects.

Increased hunger

Ghrelin receptor activation increases appetite.

Rare1 effect

Fatigue

Rarely reported.

Contraindications

Active malignancy
Pregnancy
Known hypersensitivity

Drug interactions

Limited clinical interaction data
Additive GH release when combined with GHRH analogs

Special populations

Not FDA approved. Not recommended in pregnancy or active malignancy.

Safety summary

Ipamorelin has one of the cleanest side effect profiles among GH-releasing peptides due to its selectivity. Unlike GHRP-2 and GHRP-6, it does not significantly elevate cortisol or prolactin.

Frequently asked

Does ipamorelin increase cortisol?

Unlike GHRP-2 and GHRP-6, ipamorelin has minimal impact on cortisol or prolactin release — one of its main pharmacological advantages.