Biochemistry
Disulfide Bond
A covalent bond between two cysteine residues that stabilizes peptide tertiary structure.
Definition
Disulfide bonds form between the thiol groups of cysteine side chains. They are critical for the structural stability of peptides like oxytocin, vasopressin, and insulin. Disulfide scrambling during manufacturing is a common peptide-drug impurity concern.
Related terms
Back to the full peptide glossary.