Pharmacology
GLP-1 Receptor
A class B GPCR activated by glucagon-like peptide-1; target of semaglutide, tirzepatide, and related agents.
Definition
The GLP-1 receptor (GLP-1R) is a class B G-protein coupled receptor expressed in pancreatic beta cells, the hypothalamus, the gut, and the cardiovascular system. Activation triggers insulin release, suppresses glucagon, slows gastric emptying, and reduces appetite. It is the pharmacological target of the GLP-1 agonist class.
Related terms
- GPCRG-protein coupled receptor — a family of membrane receptors that transduce signals via heterotrimeric G proteins.
- IncretinA gut hormone that stimulates insulin release in response to food intake — primarily GLP-1 and GIP.
- GLP-1 AgonistA drug that activates the GLP-1 receptor; used for diabetes and obesity.
Compounds that reference GLP-1 Receptor
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