Pharmacology
GPCR
G-protein coupled receptor — a family of membrane receptors that transduce signals via heterotrimeric G proteins.
Definition
G-protein coupled receptors are the largest family of membrane receptors in the human genome. They transduce signals from outside the cell (including peptide binding) into intracellular responses via Gαs, Gαi, Gαq, or G12/13 signaling.
Related terms
- GLP-1 ReceptorA class B GPCR activated by glucagon-like peptide-1; target of semaglutide, tirzepatide, and related agents.
- GHRH ReceptorPituitary receptor for growth hormone-releasing hormone; target of sermorelin, CJC-1295, and tesamorelin.
- Melanocortin 4 Receptor (MC4R)Hypothalamic receptor that mediates appetite suppression and sexual arousal; target of PT-141.
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