Pharmacology
Melanocortin 4 Receptor (MC4R)
Hypothalamic receptor that mediates appetite suppression and sexual arousal; target of PT-141.
Definition
MC4R is a melanocortin family GPCR expressed in the hypothalamus. Activation drives satiety, thermogenesis, and sexual arousal. PT-141 (bremelanotide) is an MC4R agonist approved for HSDD.
Related terms
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