Biochemistry

Melanocortin System

A CNS and peripheral signaling network involved in pigmentation, appetite, and sexual function.

Definition

The melanocortin system includes five receptors (MC1R–MC5R) and ligands derived from POMC. Targeting MC4R regulates appetite and sexual behavior; MC1R governs pigmentation. PT-141 and melanotan II act here.

Related terms

Melanocortin 4 Receptor (MC4R)Hypothalamic receptor that mediates appetite suppression and sexual arousal; target of PT-141.

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