Receptor

Definition

Receptors are the molecular targets of peptide drugs. Binding at a receptor — typically on the cell surface for peptides — initiates intracellular signaling cascades (e.g., cAMP, MAP kinase). Selectivity for a particular receptor subtype largely determines a peptide's effect profile.

Related terms

• LigandAny molecule — peptide, small molecule, hormone — that binds a receptor.
• GPCRG-protein coupled receptor — a family of membrane receptors that transduce signals via heterotrimeric G proteins.
• AgonistA drug that activates a receptor, producing a biological response.

Compounds that reference Receptor

• SemaglutideAn FDA-approved GLP-1 receptor agonist used for type 2 diabetes and chronic weight management.
• TirzepatideAn FDA-approved dual GIP/GLP-1 receptor agonist that has shown the highest weight loss results of any approved medication.
• CJC-1295A growth hormone-releasing hormone (GHRH) analog studied for its ability to increase growth hormone and IGF-1 levels.
• IpamorelinA selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin.
• PT-141An FDA-approved melanocortin receptor agonist used for hypoactive sexual desire disorder in premenopausal women.
• SermorelinA growth hormone-releasing hormone analog with a long history of clinical use for GH deficiency diagnosis and therapy.