In VitroPubMed ID: 1629246·1992

Thymosin alpha-1 receptor identification and signal transduction mechanisms

Naylor PH, Tseng LF, Ho WZ, et al.

Journal of Immunology, 1992

Key finding

Thymosin alpha-1 binds high-affinity receptor on CD4+ and CD8+ T-cells; activates JAK-STAT signaling and calcium mobilization.

Summary

Mechanistic study characterizing thymosin alpha-1 cell surface receptor and downstream signaling pathways in T-cells and monocytes.

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Related compound

Thymosin Alpha-1L4

A naturally occurring thymic peptide approved internationally for immune modulation, with extensive clinical data in hepatitis and cancer immunotherapy.

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