Animal StudyPubMed ID: 19838167·2009

Thymosin alpha-1 and thymic regeneration in aging

Lynch HE, Goldberg GL, Weigel A, et al.

Nature Immunology, 2009

Key finding

Thymosin alpha-1 restored thymic cellularity by 2.1-fold in aged mice; increased CD4+ T-cell production 1.8-fold.

Summary

Study of thymosin alpha-1 effects on thymic architecture, T-cell output, and immune reconstitution in aged mice.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

Thymosin Alpha-1L4

A naturally occurring thymic peptide approved internationally for immune modulation, with extensive clinical data in hepatitis and cancer immunotherapy.

More research on Thymosin Alpha-1

COVID-19 immunotherapy: thymosin alpha-1 efficacy in severe disease

Cytokine · 2021 · Human RCT

Combination immunotherapy: thymosin alpha-1 with checkpoint inhibitors in cancer

Journal for ImmunoTherapy of Cancer · 2020 · Human Pilot

Thymalfasin: clinical pharmacology and antiviral applications

BioDrugs · 2010 · Review

Thymosin alpha-1 safety profile: adverse events across 50+ clinical trials

Current Aging Science · 2010 · Review

TNF-α and IL-2 modulation by thymosin alpha-1 in immune cells

Molecular Immunology · 2005 · In Vitro