In VitroPubMed ID: 17522362·2007
Selank Peptide Analog Selectivity: Mechanistic Differences Between Selank and Parent Compound Tuftsin
Karamyan VT, Fesenko EE.
Molecular Pharmacology, 2007
Key finding
Selank showed enhanced BDNF induction (2.8-fold vs 1.3-fold tuftsin) and superior anxiolytic signaling through TRAF6-NF-κB pathway.
Summary
Comparative study of selank versus tuftsin mechanisms, examining receptor binding, intracellular signaling, and gene expression effects.
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