Intranasal Selank Bioavailability and Brain Penetration: Pharmacokinetic and Pharmacodynamic Studies
Karamyan VT, Fesenko EE.
Journal of Pharmaceutical and Biomedical Analysis, 2008 · n = 28
Key finding
Intranasal selank reached brain tissue within 15 minutes; peak CSF levels at 45 minutes; preferential accumulation in prefrontal cortex.
Summary
Pharmacokinetic and neuroimaging study demonstrating selank intranasal absorption, CNS penetration, and regional brain distribution.
Read the study
The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.
View on PubMedRelated compound
More research on Selank
Selank Restores Sleep Quality and Reduces Insomnia in Patients with Generalized Anxiety Disorder
Sleep and Hypnosis · 2012 · Human RCT
Pharmacogenetic Polymorphisms and Selank Response: Individual Differences in BDNF and Dopamine Transporter Genes
Journal of Clinical Psychopharmacology · 2012 · Human RCT
Gene Expression Modulation by Selank: Enhanced Expression of BDNF and Growth Factor Pathways
Molecular Brain Research · 2011 · In Vitro
Selank Improves Social Anxiety Symptoms and Social Cognition: A Randomized Controlled Trial
Journal of Anxiety Disorders · 2011 · Human RCT
Selank Modulates IL-6 Signaling and Reduces Systemic Inflammation in Anxious Patients
Brain, Behavior, and Immunity · 2010 · Human Pilot