Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
Alba M, Fintini D, Sagov-Grossman KL, et al.
Growth Hormone & IGF Research, 2008
Key finding
CJC-1295 produced expected GH-dependent protein profile changes, confirming genuine activation of the full GH/IGF-1 signaling cascade rather than just GH elevation.
Summary
Proteomic analysis showing CJC-1295 activation of the GH/IGF-1 axis produced characteristic changes in serum protein profiles including increased IGFBP-3.
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