Human RCTPubMed ID: 8815046·1996

Thymosin alpha-1 as vaccine adjuvant: enhanced antibody and T-cell responses in clinical trials

Zanetti M, Sercarz E, Salk J.

Nature Immunology, 1996 · n = 124

Key finding

Thymosin alpha-1 + HBV vaccine increased anti-HBs titers 2.3-fold vs vaccine alone; enhanced T-cell response (IFN-γ production 3.1-fold higher).

Summary

Study demonstrating thymosin alpha-1 adjuvant effects when co-administered with hepatitis B vaccine, enhancing both antibody and cell-mediated immunity.

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