Pharmacology
GIP Receptor
Receptor for glucose-dependent insulinotropic polypeptide; co-activated by tirzepatide and retatrutide.
Definition
GIPR is a class B GPCR for the incretin hormone GIP. Its co-activation with GLP-1R (as in tirzepatide) produces superior weight loss and glycemic control compared to GLP-1 monotherapy.
Related terms
- GPCRG-protein coupled receptor — a family of membrane receptors that transduce signals via heterotrimeric G proteins.
- IncretinA gut hormone that stimulates insulin release in response to food intake — primarily GLP-1 and GIP.
- GLP-1 ReceptorA class B GPCR activated by glucagon-like peptide-1; target of semaglutide, tirzepatide, and related agents.
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