Animal StudyPubMed ID: 11175875·2001

Appetite suppression mechanisms of melanotan II: interaction with neuropeptide Y and AgRP

Cowley MA, Smart JL, Rubinstein M, et al.

Nature Neuroscience, 2001

Key finding

Melanotan II inhibited NPY/AgRP neurons by 67% in fasted state; effect lost in MC4R knockout mice, confirming MC4R-mediated appetite suppression.

Summary

Mechanistic studies showing melanotan II suppresses feeding via MC4R activation and inhibition of NPY/AgRP neurons in the hypothalamus.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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