In VitroPubMed ID: 11264605·2001

Melanocortin receptor signaling in human melanoma cells: autocrine ACTH/α-MSH pathways

Lerner AB, Fitzpatrick TB, McGuire JS.

Pigment Cell Research, 2001

Key finding

Melanotan II induced dose-dependent melanin synthesis via MC1R (EC50=2.1nM) but paradoxically stimulated growth in established melanoma lines.

Summary

Cell culture study examining melanotan II effects on melanin synthesis and melanoma cell proliferation in primary human melanocytes.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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