ReviewPubMed ID: 11543635·2001

Central melanocortin system and melanotan II: behavioral and neuronal mapping

Cone RD, Cowley MA, Butler AA, et al.

Annual Review of Neuroscience, 2001

Key finding

Melanotan II crosses BBB via organic anion transporter; activates multiple CNS melanocortin populations with diverse behavioral effects beyond tanning.

Summary

Comprehensive review of central melanocortin system anatomy, function, and effects of melanocortin agonism on appetite, energy expenditure, and sexual behavior.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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