Animal StudyPubMed ID: 12105179·2002

Melanotan II-induced systemic hypertension and cardiovascular effects

Goel A, Campbell SJ, Bj Zeisler, et al.

Hypertension, 2002

Key finding

Melanotan II increased systolic BP by 8-12 mmHg acutely (MC1R-mediated); chronic dosing led to tolerance; effect reversible upon discontinuation.

Summary

Study of melanotan II effects on blood pressure, heart rate, and cardiac hemodynamics in normotensive and hypertensive rats.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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