Animal StudyPubMed ID: 16422843·2005

Sexual function benefits of melanocortin agonism: development toward PT-141

Wessells H, Fuciarelli K, Hannan JL, et al.

Journal of Sexual Medicine, 2005

Key finding

Melanotan II enhanced erectile response in anesthetized rats (MCR agonism-dependent) and increased female sexual behavior in conscious animals.

Summary

Preclinical studies establishing melanotan II effects on erectile function and libido in male and female rats via melanocortin pathways.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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