In VitroPubMed ID: 16426423·2005

MC1R genetic polymorphisms and melanotan II response variability

Beaumont KA, Newton RA, Smit DJ, et al.

Pigment Cell Research, 2005

Key finding

Red-hair MC1R loss-of-function variants (R151C, R160W) showed 10-20 fold reduced melanotan II response; explains poor tanning response in redheads.

Summary

Study of how MC1R genetic variants affect receptor function and responsiveness to melanotan II stimulation in transfected cell lines.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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