Animal StudyPubMed ID: 20219669·2010

Cartilage Protective Effects of AOD 9604 in Transgenic Mice with Accelerated Osteoarthritis

Wu X, Rasmussen JC, Sawicki G, et al.

Osteoarthritis and Cartilage, 2010

Key finding

AOD 9604 reduced cartilage damage score by 67%, decreased MMP-13 activity by 58%, and preserved joint space width.

Summary

Transgenic mouse model of accelerated OA treated with AOD 9604; assessed cartilage damage, MMP activity, and joint space.

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