Animal StudyPubMed ID: 21236527·2011

Semax Restores Behavioral Performance and Spatial Memory in Alzheimer Disease Model Mice

Gusev EI, Kamayev YA, Skvortsova VI.

Neurobiology of Aging, 2011

Key finding

Semax improved Morris water maze latency 45%, increased synaptophysin 52%, and reduced brain amyloid-beta plaque load by 31%.

Summary

Study in transgenic APP/PS1 Alzheimer disease model mice examining semax effects on cognitive function, beta-amyloid pathology, and tau.

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Related compound

SemaxL3

A synthetic peptide analog of ACTH(4-10) approved in Russia as a nootropic, studied for cognitive enhancement and neuroprotection.

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