Animal StudyPubMed ID: 33033295·2020

Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway

Hsieh MJ, Lee CH, Chueh HY, et al.

Scientific Reports, 2020

Key finding

BPC-157 promotes angiogenesis and vasodilation through dual nitric oxide pathways, supporting vascular stability and blood flow to healing tissues.

Summary

Study elucidating a key mechanism of BPC-157 action: activation of both VEGF-dependent (VEGFR2-PI3K-Akt-eNOS) and VEGF-independent (Src-Caveolin-1-eNOS) pathways to nitric oxide production.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

BPC-157L2

A gastric pentadecapeptide studied extensively in animal models for tissue healing, gut protection, and cytoprotective properties. Despite over 100 preclinical studies, human clinical data remains extremely limited.

More research on BPC-157

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

Sports Health · 2025 · Review

Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study

Alternative Therapies in Health and Medicine · 2025 · Human Pilot

The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity

Pharmaceuticals · 2024 · Review

Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

Frontiers in Pharmacology · 2021 · Review

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

Molecules · 2014 · In Vitro