ReviewPubMed ID: 38675421·2024

The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity

Sikiric P, Drmic D, Boban Blagaic A, et al.

Pharmaceuticals, 2024

Key finding

BPC-157 demonstrates broad cytoprotective activity mediated through interactions with multiple neurotransmitter systems and the NO system, functioning as a unique cytoprotection mediator stable in gastric juice.

Summary

Major 2024 review covering BPC-157 pleiotropic effects across organ systems, including its interactions with the dopamine, serotonin, GABA, and NO systems. Notes BPC-157 is not destroyed in human gastric juice.

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Related compound

BPC-157L2

A gastric pentadecapeptide studied extensively in animal models for tissue healing, gut protection, and cytoprotective properties. Despite over 100 preclinical studies, human clinical data remains extremely limited.

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