Animal StudyPubMed ID: 9247226·1997

Melanocortin pathway regulation of appetite: MC3R vs MC4R selectivity in feeding

Seeley RJ, Yagaloff KA, Fisher SL, et al.

Science, 1997

Key finding

MC4R selective agonism suppressed feeding; MC1R activation promoted tanning and caused transient hypertension; melanotan II affects both pathways non-selectively.

Summary

Mechanistic study establishing that non-selective melanocortin agonism (like melanotan II) suppresses feeding through MC4R but has off-target MC1R effects.

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Related compound

Melanotan IIL3

A melanocortin receptor agonist that stimulates melanin production (tanning) and has sexual function effects. Significant safety concerns.

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