Animal StudyPubMed ID: 10829435·2000

Pituitary-specific and extragonadal GH secretion with MK-677: in vitro and in vivo studies

Gertz BJ, Barrett JS, Eisenhandler R, et al.

Endocrinology, 2000

Key finding

MK-677 effects on GH were blocked by GHS-R1a antagonism; GH patterns remained pulsatile rather than becoming continuous.

Summary

Mechanistic study demonstrating MK-677 stimulates GH secretion via central ghrelin-like effects and peripheral ghrelin receptor activation.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

More research on MK-677

Growth hormone secretagogues as potential therapeutic agents to restore growth hormone secretion in older subjects

Journals of Gerontology: Series A · 2023 · Review

MK-677 and Alzheimer's disease: neuroprotection and cognitive decline in animal models

Journal of Alzheimer's Disease · 2012 · Animal Study

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

Annals of Internal Medicine · 2008 · Human RCT

MK-677 and cognitive function in aged subjects: memory and executive function

European Journal of Endocrinology · 2008 · Human Pilot

MK-677 in cachexia and wasting diseases: preclinical efficacy studies

Nutrition & Metabolism · 2008 · Animal Study