Animal StudyPubMed ID: 18325083·2008

MK-677 in cachexia and wasting diseases: preclinical efficacy studies

DeBoer MD, Zhu X, Dressman J, et al.

Nutrition & Metabolism, 2008

Key finding

MK-677 partially reversed cancer-induced appetite loss; increased food intake 34-42%; attenuated protein wasting by 28%.

Summary

Studies of MK-677 in cancer cachexia and AIDS wasting animal models, examining effects on food intake, body weight, and protein metabolism.

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The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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