Human RCTPubMed ID: 18981485·2008

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

Nass R, Pezzoli SS, Oliveri MC, et al.

Annals of Internal Medicine, 2008 · n = 65

Key finding

MK-677 increased GH and IGF-1 to youthful levels for 12 months but did not improve strength or function, and insulin sensitivity declined significantly.

Summary

One-year RCT in 65 healthy adults aged 60-81. MK-677 25mg daily increased GH by 97%, restored IGF-1 to youthful levels, and increased fat-free mass, but worsened insulin sensitivity.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

More research on MK-677

Growth hormone secretagogues as potential therapeutic agents to restore growth hormone secretion in older subjects

Journals of Gerontology: Series A · 2023 · Review

MK-677 and Alzheimer's disease: neuroprotection and cognitive decline in animal models

Journal of Alzheimer's Disease · 2012 · Animal Study

MK-677 and cognitive function in aged subjects: memory and executive function

European Journal of Endocrinology · 2008 · Human Pilot

MK-677 in cachexia and wasting diseases: preclinical efficacy studies

Nutrition & Metabolism · 2008 · Animal Study

MK-677 immunological effects: T-cell and B-cell function in aged subjects

Journal of Gerontology: Series A · 2007 · Human Pilot