Animal StudyPubMed ID: 22156049·2012

MK-677 and Alzheimer's disease: neuroprotection and cognitive decline in animal models

Dozier S, Johnson A, Grier K, et al.

Journal of Alzheimer's Disease, 2012

Key finding

MK-677 reduced amyloid plaque burden by 18% and improved Morris water maze performance; effects mediated by IGF-1-MAPK pathway.

Summary

Study of MK-677 effects in transgenic Alzheimer's disease mice, measuring amyloid burden, neuroinflammation, and cognitive function.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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