Human RCTPubMed ID: 11103584·2000

MK-677 insulin sensitivity and fasting glucose: mechanisms of deterioration

Svensson J, Lönn L, Jansson JO, et al.

Metabolism: Clinical & Experimental, 2000 · n = 39

Key finding

MK-677 increased fasting glucose 6.2 ± 1.8 mg/dL and fasting insulin 68%; insulin resistance index (HOMA) increased 74% despite raised IGF-1.

Summary

Study of insulin dynamics in MK-677 trials, examining fasting glucose, insulin levels, and OGTT results with mechanistic analysis.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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