Animal StudyPubMed ID: 11420318·2001

MK-677 and ghrelin signaling: cross-talk with other metabolic hormones

Horvath TL, Naftolin F, Leranth C.

Molecular Psychiatry, 2001

Key finding

MK-677 ghrelin mimicry bypasses leptin signaling; activates NPY/AgRP neurons; effect independent of actual nutritional state.

Summary

Mechanistic study of ghrelin receptor signaling in hypothalamus and interactions with leptin, insulin, and NPY/AgRP pathways.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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