Human RCTPubMed ID: 12196557·2002

MK-677 withdrawal effects and GH rebound

Broglio F, Benso A, Castiglioni C, et al.

Journal of Clinical Endocrinology & Metabolism, 2002 · n = 16

Key finding

GH returned to baseline within 24 hours of MK-677 discontinuation; no rebound elevation; GH pulse frequency normalized within 48 hours.

Summary

Study of GH secretion patterns immediately after MK-677 discontinuation, examining rebound phenomena and return to baseline.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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