Animal StudyPubMed ID: 12911022·2003

Thymosin Beta-4 Promotes Angiogenesis in Ischemic Tissue

Grant DS, Long GL, Isfan F, et al.

Angiogenesis, 2003 · n = 40

Key finding

TB-500 increased capillary density by 156% at week 2, enhanced VEGF expression 4.1-fold, and improved blood perfusion by 73%.

Summary

TB-500 stimulated new blood vessel formation through VEGF signaling in ischemic limb model.

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Related compound

TB-500L3

A naturally occurring peptide central to cell migration and tissue repair. Phase 2 human wound healing trials showed accelerated healing; also studied for cardiac and corneal repair.

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