In VitroPubMed ID: 20140613·2010

Thymosin Beta-4 Regulates Inflammation and Promotes Macrophage M2 Polarization

Sosne G, Qiu P, Christopherson PL, et al.

Journal of Molecular Medicine, 2010 · n = 4

Key finding

TB-500 increased M2 macrophage markers (CD206, Arg1) by 6.8-fold, reduced pro-inflammatory TNF-α by 72%, enhanced IL-10 by 4.2-fold.

Summary

TB-500 modulated innate immunity through macrophage polarization toward anti-inflammatory M2 phenotype.

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Related compound

TB-500L3

A naturally occurring peptide central to cell migration and tissue repair. Phase 2 human wound healing trials showed accelerated healing; also studied for cardiac and corneal repair.

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