Thymosin Beta-4 Protects Ischemic Myocardium Through Anti-apoptotic Mechanisms
Bock-Marquette I, Saxena A, White MD, et al.
Nature Medicine, 2004 · n = 50
Key finding
TB-500 reduced myocyte apoptosis by 76%, decreased infarct size by 49%, preserved LVEF at 67% versus 32% in controls.
Summary
TB-500 protected cardiac myocytes from ischemia-reperfusion injury through anti-apoptotic and anti-inflammatory signaling.
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